Curated Information
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Curated Information Page
PubMed Id: 21677641 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Autry AE, et al. (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475, 91-5 21677641
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T57-p - eEF2 (mouse)
Orthologous residues
eEF2 (human): T57‑p, eEF2 (mouse): T57‑p, eEF2 (rat): T57‑p, eEF2 (rabbit): T56‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  major depressive disorder
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', neuron-'brain, hippocampus'
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
2-amino-5-phosphonopentanoic acid decrease
ketamine decrease
TTX no change compared to control
TTX 2-amino-5-phosphonopentanoic acid no effect upon treatment-induced decrease
TTX ketamine no effect upon treatment-induced decrease
rottlerin decrease
NH125 decrease

S2448-p - mTOR (mouse)
Orthologous residues
mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  major depressive disorder
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', neuron-'brain, hippocampus'
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ketamine no change compared to control
ketamine BDNF (human) no change compared to control


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