Curated Information

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Curated Information Page

PubMed Id: 12700239

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Song DH, et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem 278, 24018-25 12700239

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T393-p - CTNNB1 (human)

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Orthologous residues

CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CK2-A1 (mouse)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
apigenin				decrease
wortmannin				no change compared to control

Downstream Regulation

Effect of modification (function): protein stabilization

Effect of modification (process): transcription, altered

Comments: Underphosphorylated T393A mutant has reduced stability and co-transcriptional activity.

T393-p - CTNNB1 (mouse)

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Orthologous residues

CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p

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