Curated Information
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Curated Information Page
PubMed Id: 12700239 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Song DH, et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem 278, 24018-25 12700239
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T393-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
apigenin decrease
wortmannin no change compared to control
Downstream Regulation
 Effect of modification (function):  protein stabilization
 Effect of modification (process):  transcription, induced
 Comments:  Underphosphorylated T393A mutant has reduced stability and co-transcriptional activity.

T393-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p


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