Curated Information
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Curated Information Page
PubMed Id: 10347142 
Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ (1999) Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem 274, 15971-4 10347142
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S412-p - ARRB1 (human)
Orthologous residues
ARRB1 (human): S412‑p, ARRB1 iso2 (human): S404‑p, ARRB1 (mouse): S412‑p, ARRB1 (rat): S412‑p, ARRB1 (cow): S412‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  293 (epithelial) [ADRB2 (human)], 293 (epithelial) [ARRB1 (human)], 293 (epithelial) [MEK1 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
KINASE ERK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) transfection of constitutively active enzyme, transfection of inactive enzyme constitutively active and dominant-negative MEK1 constructs have been used in this study
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ADRB2 (human) Disrupts receptor internalization, altered co-immunoprecipitation

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