Curated Information
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Curated Information Page
PubMed Id: 18248330 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Perander M, et al. (2008) The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. Biochem J 411, 613-22 18248330
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S186-p - ERK4 (human)
Orthologous residues
ERK4 (human): S186‑p, ERK4 (mouse): S186‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical), SF9
 Cellular systems studied:  cell lines
 Species studied:  human, insect
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAPKAPK5 (human) Induces enzymatic activity, induced, intracellular localization co-immunoprecipitation
 Comments: 


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