Curated Information
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Curated Information Page
PubMed Id: 18250156 
Tang X, et al. (2008) A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol 28, 2559-66 18250156
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T320-p - PPP1CA (human)
Orthologous residues
PPP1CA (human): T320‑p, PPP1CA (mouse): T320‑p, PPP1CA (rat): T320‑p, PPP1CA (rabbit): T320‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation decrease

S44-p - PPP1R2 (human)
Orthologous residues
PPP1R2 (human): S44‑p, PPP1R2 (mouse): S45‑p, PPP1R2 (rat): S44‑p, PPP1R2 (rabbit): S44‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  293T (epithelial), GM01526 (fibroblast), GM0536 (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATM (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
Downstream Regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP1CA (human) Disrupts enzymatic activity, induced co-immunoprecipitation
 Comments:  in response to IR-induced DNA damage


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