Curated Information

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Curated Information Page

PubMed Id: 18250156

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Tang X, et al. (2008) A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol 28, 2559-66 18250156

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T320-p - PPP1CA (human)

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Orthologous residues

PPP1CA (human): T320‑p, PPP1CA (mouse): T320‑p, PPP1CA (rat): T320‑p, PPP1CA (rabbit): T320‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293T (epithelial)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				decrease

S44-p - PPP1R2 (human)

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Orthologous residues

PPP1R2 (human): S44‑p, PPP1R2 (mouse): S45‑p, PPP1R2 (rat): S44‑p, PPP1R2 (rabbit): S44‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Disease tissue studied: ataxia-telangiectasia

Relevant cell lines - cell types - tissues: 293T (epithelial), GM01526 (fibroblast), GM0536 (fibroblast), HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ATM (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ATM (human)	genetic knockout/knockin of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase

Downstream Regulation

Effect of modification (process): cell cycle regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
PPP1CA (human)		Disrupts	enzymatic activity, induced		co-immunoprecipitation

Comments: in response to IR-induced DNA damage

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