Curated Information
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Curated Information Page
PubMed Id: 18305097 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cha SK, Wu T, Huang CL (2008) Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am J Physiol Renal Physiol 294, F1212-21 18305097
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S299-p - TRPV5 (rabbit)
Orthologous residues
TRPV5 (human): S299‑p, TRPV5 (mouse): S292‑p, TRPV5 (rabbit): S299‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
genistein increase
OAG increase
GF109203X OAG inhibit treatment-induced increase
phorbol ester increase
GF109203X phorbol ester inhibit treatment-induced increase
PTH increase
GF109203X PTH inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization
 Comments:  inhibits caveolar endocytosis of TRPV5

S654-p - TRPV5 (rabbit)
Orthologous residues
TRPV5 (human): S654‑p, TRPV5 (mouse): S647‑p, TRPV5 (rabbit): S654‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
genistein increase
OAG increase
GF109203X OAG inhibit treatment-induced increase
phorbol ester increase
GF109203X phorbol ester inhibit treatment-induced increase
PTH increase
GF109203X PTH inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization
 Comments:  inhibits caveolar endocytosis of TRPV5


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