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PubMed Id: 12637502

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Cameron SJ, et al. (2003) Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. J Biol Chem 278, 18682-8 12637502

S255-p - Cx43 (rat)

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Orthologous residues

Cx43 (human): S255‑p, Cx43 (mouse): S255‑p, Cx43 (rat): S255‑p, Cx43 (rabbit): S255‑p, Cx43 (hamster): N255‑p

Characterization

Methods used to characterize site in vivo: electrophoretic mobility shift, mutation of modification site

Relevant cell lines - cell types - tissues: 293 (epithelial) [Cx43 (rat)], 293 (epithelial) [MEK5 (human)]

Cellular systems studied: cell lines

Species studied: human

Comments: constitutively active MEK5 activate endogenous ERK5 which phosphorylates CX43 on S254.

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ERK5 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ERK5 (human)	genetic transfer of dominant-negative enzyme

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