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PubMed Id: 12818176

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Putcha GV, et al. (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38, 899-914 12818176

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S473-p - Akt1 (human)

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Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NGF withdrawal, Boc-D-FMK				decrease

S63-p - Jun (human)

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Orthologous residues

Jun (human): S63‑p, Jun (mouse): S63‑p, Jun (rat): S63‑p

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NGF withdrawal, Boc-D-FMK				increase

S65-p - Bim (mouse)

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Orthologous residues

Bim (human): S69‑p, Bim iso2 (human): ‑, Bim iso3 (human): ‑, Bim (mouse): S65‑p, Bim (rat): S65‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, cerebellar granule'-brain, 293 (epithelial)

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	JNK3 (human)
KINASE	JNK2 (human)
KINASE	JNK1 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
CEP1347				decrease
SP600125				decrease
NGF withdrawal, Boc-D-FMK				decrease

Downstream Regulation

Effect of modification (process): apoptosis, induced

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