Curated Information
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Curated Information Page
PubMed Id: 22017875 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gao D, et al. (2011) mTOR drives its own activation via SCF(╬▓TrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell 44, 290-303 22017875
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S6-p - Deptor (human)
Orthologous residues
Deptor (human): S6‑p, Deptor (mouse): S6‑p, Deptor (rat): A18‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

T7-p - Deptor (human)
Orthologous residues
Deptor (human): T7‑p, Deptor (mouse): G7‑p, Deptor (rat): A19‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

T149-p - Deptor (human)
Orthologous residues
Deptor (human): T149‑p, Deptor (mouse): T149‑p, Deptor (rat): T256‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)

S168-p - Deptor (human)
Orthologous residues
Deptor (human): S168‑p, Deptor (mouse): S168‑p, Deptor (rat): S275‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S235-p - Deptor (human)
Orthologous residues
Deptor (human): S235‑p, Deptor (mouse): S235‑p, Deptor (rat): S342‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S244-p - Deptor (human)
Orthologous residues
Deptor (human): S244‑p, Deptor (mouse): S244‑p, Deptor (rat): S351‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

T259-p - Deptor (human)
Orthologous residues
Deptor (human): T259‑p, Deptor (mouse): T259‑p, Deptor (rat): T366‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S260-p - Deptor (human)
Orthologous residues
Deptor (human): S260‑p, Deptor (mouse): S260‑p, Deptor (rat): S367‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S263-p - Deptor (human)
Orthologous residues
Deptor (human): S263‑p, Deptor (mouse): S263‑p, Deptor (rat): S370‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)

S265-p - Deptor (human)
Orthologous residues
Deptor (human): S265‑p, Deptor (mouse): S265‑p, Deptor (rat): S372‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE mTOR (human)

S267-p - Deptor (human)
Orthologous residues
Deptor (human): S267‑p, Deptor (mouse): S267‑p, Deptor (rat): S374‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S280-p - Deptor (human)
Orthologous residues
Deptor (human): S280‑p, Deptor (mouse): S280‑p, Deptor (rat): S387‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S283-p - Deptor (human)
Orthologous residues
Deptor (human): S283‑p, Deptor (mouse): S283‑p, Deptor (rat): S390‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S286-p - Deptor (human)
Orthologous residues
Deptor (human): S286‑p, Deptor (mouse): S286‑p, Deptor (rat): S393‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
KINASE mTOR (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation

S287-p - Deptor (human)
Orthologous residues
Deptor (human): S287‑p, Deptor (mouse): S287‑p, Deptor (rat): S394‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)

S293-p - Deptor (human)
Orthologous residues
Deptor (human): S293‑p, Deptor (mouse): S293‑p, Deptor (rat): S400‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE mTOR (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation

T295-p - Deptor (human)
Orthologous residues
Deptor (human): T295‑p, Deptor (mouse): T295‑p, Deptor (rat): T402‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE mTOR (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation

S297-p - Deptor (human)
Orthologous residues
Deptor (human): S297‑p, Deptor (mouse): S297‑p, Deptor (rat): S404‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S298-p - Deptor (human)
Orthologous residues
Deptor (human): S298‑p, Deptor (mouse): S298‑p, Deptor (rat): S405‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S299-p - Deptor (human)
Orthologous residues
Deptor (human): S299‑p, Deptor (mouse): S299‑p, Deptor (rat): S406‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE mTOR (human)
KINASE mTOR (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation


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