Curated Information
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Curated Information Page
PubMed Id: 21892182 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lee J, et al. (2011) p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med 17, 1251-60 21892182
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T48-p - XBP1 (mouse) ▲
Orthologous residues
XBP1 (human): L55‑p, XBP1 iso2 (human): L55‑p, XBP1 (mouse): T48‑p, XBP1 iso2 (mouse): T48‑p, XBP1 (rat): T48‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), adipose tissue, liver, muscle
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE p38-alpha (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p38-alpha (mouse) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
fasting decrease in lean (wt) mice
refeeding increase in lean (wt ) mice
SB203580 refeeding inhibit treatment-induced increase in lean (wt) mice
refeeding decrease in obese (ob/ob) mice
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  important for nuclear translocation of XBP1- not in obese (ob/ob) mice

S61-p - XBP1 (mouse) ▲
Orthologous residues
XBP1 (human): S68‑p, XBP1 iso2 (human): S68‑p, XBP1 (mouse): S61‑p, XBP1 iso2 (mouse): S61‑p, XBP1 (rat): S61‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), adipose tissue, liver, MEF (fibroblast), muscle
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE p38-alpha (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p38-alpha (mouse) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
fasting decrease in lean (wt) mice
refeeding increase in lean (wt ) mice
SB203580 refeeding inhibit treatment-induced increase in lean (wt) mice
refeeding decrease in obese (ob/ob) mice
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  important for nuclear translocation of XBP1- not in obese (ob/ob) mice


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