Curated Information
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Curated Information Page
PubMed Id: 21969607 
Fan J, et al. (2011) Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Mol Cell Biol 31, 4938-50 21969607
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y10-p - LDH-A (human)
Orthologous residues
LDH‑A (human): Y10‑p, LDH‑A iso2 (human): Y10‑p, LDH‑A iso3 (human): Y39‑p, LDH‑A (mouse): V10‑p, LDH‑A (rat): V10‑p, LDH‑A (chicken): H9‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, erythroid leukemia, lung cancer, non-small cell lung cancer, prostate cancer
 Relevant cell lines - cell types - tissues:  212LN, 22Rv1 (prostate cell), 686LN, EOL-1 (myeloid), HEL (erythroid), K562 (erythroid), KG-1a (myeloid), MDA-MB231 (breast cell), Molm 14 (myeloid), NCI-H1299 (pulmonary), NCI-H157 (pulmonary), NCI-H358 (pulmonary), PC3 (prostate cell), Tu212, Tu686
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE FGFR1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TKI258 decrease
AG490 decrease
imatinib decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Effect of modification (process):  carcinogenesis, induced, cell growth, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LDH-A (human) Induces affinity chromatography

Y83-p - LDH-A (human)
Orthologous residues
LDH‑A (human): Y83‑p, LDH‑A iso2 (human): Y83‑p, LDH‑A iso3 (human): Y112‑p, LDH‑A (mouse): Y83‑p, LDH‑A (rat): Y83‑p, LDH‑A (chicken): Y83‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE FGFR1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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