Curated Information
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Curated Information Page
PubMed Id: 21969607 
Fan J, et al. (2011) Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Mol Cell Biol 31, 4938-50 21969607
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y10-p - LDH-A (human)
Orthologous residues
LDH‑A (human): Y10‑p, LDH‑A iso2 (human): Y10‑p, LDH‑A iso3 (human): Y39‑p, LDH‑A (mouse): V10‑p, LDH‑A (rat): V10‑p, LDH‑A (chicken): H9‑p
 Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, erythroid leukemia, lung cancer, non-small cell lung cancer, prostate cancer
 Relevant cell lines - cell types - tissues:  212LN, 22Rv1 (prostate cell), 686LN, EOL-1 (myeloid), HEL (erythroid), K562 (erythroid), KG-1a (myeloid), MDA-MB231 (breast cell), Molm 14 (myeloid), NCI-H1299 (pulmonary), NCI-H157 (pulmonary), NCI-H358 (pulmonary), PC3 (prostate cell), Tu212, Tu686
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE FGFR1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TKI258 decrease
AG490 decrease
imatinib decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Effect of modification (process):  carcinogenesis, induced, cell growth, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LDH-A (human) Induces affinity chromatography

Y83-p - LDH-A (human)
Orthologous residues
LDH‑A (human): Y83‑p, LDH‑A iso2 (human): Y83‑p, LDH‑A iso3 (human): Y112‑p, LDH‑A (mouse): Y83‑p, LDH‑A (rat): Y83‑p, LDH‑A (chicken): Y83‑p
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE FGFR1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

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