|
Orthologous residues
|
|
H2B (human): S15‑p, H2B (mouse): S15‑p, H2B (rat): S15‑p, H2B (cow): S14‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
|
|
Disease tissue studied:
leukemia, liver cancer, lymphoma, B cell lymphoma
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial), 3T3 (fibroblast), DT40 (B lymphocyte), HeLa (cervical), HepG2 (hepatic), HL60 (myeloid), IMR-90 (fibroblast)
|
|
Cellular systems studied:
cell lines, tissue
|
|
Species studied:
chicken, frog, human, mouse
|
|
Comments:
Frog tail
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
MST1 (human)
|
transfection of inactive enzyme, phospho-antibody, transfection of wild-type enzyme, transfection of constitutively active enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
etoposide
|
|
|
|
increase
|
|
|
UV
|
|
|
|
increase
|
|
|
anti-Fas
|
|
|
|
increase
|
|
|
anisomycin
|
|
|
|
increase
|
|
|
MMS
|
|
|
|
increase
|
|
|
VP-16
|
|
|
|
increase
|
|
|
