Curated Information
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PubMed Id: 12757711 
Cheung WL, et al. (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113, 507-17 12757711
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S14-p - H2B (human)
Orthologous residues
H2B (human): S14‑p, H2B (mouse): S14‑p, H2B (rat): S14‑p, H2B (cow): S14‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  leukemia, liver cancer, lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast), DT40 (B lymphocyte), HeLa (cervical), HepG2 (hepatic), HL60 (myeloid), IMR-90 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  chicken, frog, human, mouse
 Comments:  Frog tail
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MST1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MST1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
etoposide increase
UV increase
anti-Fas increase
anisomycin increase
MMS increase
VP-16 increase

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