Curated Information
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Curated Information Page
PubMed Id: 10660621 
Rowan BG, Weigel NL, O'Malley BW (2000) Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. J Biol Chem 275, 4475-83 10660621
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S372-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S372‑p, SRC‑1 iso2 (human): S372‑p, SRC‑1 (mouse): S372‑p, SRC‑1 (rat): S310‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progesterone no change compared to control
EGF increase

S395-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S395‑p, SRC‑1 iso2 (human): S395‑p, SRC‑1 (mouse): S395‑p, SRC‑1 (rat): S333‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control

S517-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S517‑p, SRC‑1 iso2 (human): S517‑p, SRC‑1 (mouse): S518‑p, SRC‑1 (rat): S456‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control

S569-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S569‑p, SRC‑1 iso2 (human): S569‑p, SRC‑1 (mouse): S570‑p, SRC‑1 (rat): S508‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control

S1033-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S1033‑p, SRC‑1 iso2 (human): S1033‑p, SRC‑1 (mouse): S1039‑p, SRC‑1 (rat): S974‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control

T1179-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): T1179‑p, SRC‑1 iso2 (human): T1179‑p, SRC‑1 (mouse): T1185‑p, SRC‑1 (rat): T1120‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control

S1185-p - SRC-1 (human)
Orthologous residues
SRC‑1 (human): S1185‑p, SRC‑1 iso2 (human): S1185‑p, SRC‑1 (mouse): S1191‑p, SRC‑1 (rat): S1126‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
progesterone no change compared to control


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