Curated Information
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Curated Information Page
PubMed Id: 21982370 
Cohen S, et al. (2011) Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function. Neuron 72, 72-85 21982370
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S133-p - CREB (mouse)
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', 'neuron, cortical'-brain [MECP2 (mouse), genetic knockin], neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Comments:  MeCP2 mutation link to Rett syndrome

K4-m3 - H3 (mouse)
Orthologous residues
H3 (human): K4‑m3, H3 (mouse): K4‑m3, H3 iso2 (mouse): K4‑m3, H3 iso3 (mouse): K4‑m3, H3 (rat): K4‑m3, H3 iso3 (rat): K4‑m3, H3 (pig): K4‑m3, H3 (chicken): K4‑m3, H3 (cow): K4‑m3
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
depolarization increase

S421-p - MECP2 (mouse)
Orthologous residues
MECP2 (human): S423‑p, MECP2 iso2 (human): S435‑p, MECP2 (mouse): S421‑p, MECP2 iso2 (mouse): S438‑p, MECP2 (rat): S421‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', 'neuron, cortical'-brain [MECP2 (mouse), genetic knockin], neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Comments:  MeCP2 mutation link to Rett syndrome
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
depolarization increase
okadaic acid depolarization inhibit treatment-induced increase
okadaic acid increase
depolarization increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered, cytoskeletal reorganization
 Comments:  Regulates dendritic remodeling, membrane depolarization; neuronal activation leading to S421 phosphorylation and global chromatin response; S421A mutant mice have behavioral defects in response to novel experience.


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