Curated Information
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Curated Information Page
PubMed Id: 21982370 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cohen S, et al. (2011) Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function. Neuron 72, 72-85 21982370
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S133-p - CREB (mouse)
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', 'neuron, cortical'-brain [MeCP2 (mouse), genetic knockin], neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Comments:  MeCP2 mutation link to Rett syndrome

K5-m3 - H3 (mouse)
Orthologous residues
H3 (human): K5‑m3, H3 (mouse): K5‑m3, H3 iso2 (mouse): K5‑m3, H3 iso3 (mouse): K5‑m3, H3 (rat): K5‑m3, H3 iso3 (rat): K5‑m3, H3 (pig): K5‑m3, H3 (chicken): K5‑m3, H3 (cow): K5‑m3
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
depolarization increase

S421-p - MeCP2 (mouse)
Orthologous residues
MeCP2 (human): S423‑p, MeCP2 iso2 (human): S435‑p, MeCP2 (mouse): S421‑p, MeCP2 iso2 (mouse): S438‑p, MeCP2 (rat): S421‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, forebrain', 'neuron, cortical'-brain [MeCP2 (mouse), genetic knockin], neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Comments:  MeCP2 mutation link to Rett syndrome
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
depolarization increase
okadaic acid depolarization inhibit treatment-induced increase
okadaic acid increase
depolarization increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered, cytoskeletal reorganization
 Comments:  Regulates dendritic remodeling, membrane depolarization; neuronal activation leading to S421 phosphorylation and global chromatin response; S421A mutant mice have behavioral defects in response to novel experience.


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