Curated Information
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Curated Information Page
PubMed Id: 12748172 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ouyang T, et al. (2003) Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). J Biol Chem 278, 30028-36 12748172
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S354-p - NIPA (human)
Orthologous residues
NIPA (human): S354‑p, NIPA (mouse): S353‑p, NIPA iso2 (mouse): S353‑p, NIPA iso3 (mouse): , NIPA (rat): S353‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  293 (epithelial), BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ALK (human) increase Phosphorylation dependent on coexpression of NPM-ALK (or another kinase-active ALK fusion), which appears to activate an unknown S/T kinase.
Downstream Regulation
 Effect of modification (process):  apoptosis, altered


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