Curated Information
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Curated Information Page
PubMed Id: 21474066 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Kennedy AL, et al. (2011) Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell 42, 36-49 21474066
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (human) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  pancreatic
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
pancreatic cancer increased phosphorylation associated with poor overall survival

S9-p - GSK3B (human) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast), pancreatic
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Akt1 (human) increase constitutively active Akt1
HRas (human) no change compared to control activated HRas
HRas (human) Akt1 (human) no effect upon treatment-induced increase activated HRas
rapamycin no change compared to control
Associated Diseases
Diseases: Alterations: Comments:
pancreatic cancer increased phosphorylation associated with poor overall survival

S2448-p - mTOR (human) ▲
Orthologous residues
mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  pancreatic
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
pancreatic cancer increased phosphorylation associated with poor overall survival

T412-p - p70S6K (human) ▲
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Akt1 (human) increase constitutively active Akt1
HRas (human) no change compared to control activated HRas
HRas (human) Akt1 (human) no effect upon treatment-induced increase activated HRas
rapamycin no change compared to control

S780-p - Rb (human) ▲
Orthologous residues
Rb (human): S780‑p, Rb (mouse): S773‑p, Rb (rat): S772‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HRas (human) increase activated HRas
Akt1 (human) decrease activated Akt1

S807-p - Rb (human) ▲
Orthologous residues
Rb (human): S807‑p, Rb (mouse): S800‑p, Rb (rat): S799‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HRas (human) increase activated HRas
Akt1 (human) decrease activated Akt1

S811-p - Rb (human) ▲
Orthologous residues
Rb (human): S811‑p, Rb (mouse): S804‑p, Rb (rat): S803‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HRas (human) increase activated HRas
Akt1 (human) decrease activated Akt1

S473-p - Akt1 (mouse) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  pancreatic
 Cellular systems studied:  tissue
 Species studied:  mouse

S9-p - GSK3B (mouse) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  pancreatic
 Cellular systems studied:  tissue
 Species studied:  mouse

S2448-p - mTOR (mouse) ▲
Orthologous residues
mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  pancreatic cancer
 Relevant cell lines - cell types - tissues:  pancreatic
 Cellular systems studied:  tissue
 Species studied:  mouse


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