Curated Information
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Curated Information Page
PubMed Id: 21876001 
Zheng Y, et al. (2011) Ras-Induced and Extracellular Signal-Regulated Kinase 1 and 2 Phosphorylation-Dependent Isomerization of Protein Tyrosine Phosphatase (PTP)-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST. Mol Cell Biol 31, 4258-69 21876001
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y397-p - FAK (human)
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y428‑p, FAK iso3 (mouse): Y397‑p, FAK iso4 (mouse): Y397‑p, FAK iso9 (mouse): , FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):

S910-p - FAK (human)
Orthologous residues
FAK (human): S910‑p, FAK iso2 (human): S737‑p, FAK iso5 (human): S923‑p, FAK (mouse): S948‑p, FAK iso3 (mouse): S910‑p, FAK iso4 (mouse): S913‑p, FAK iso9 (mouse): S218‑p, FAK (rat): S913‑p, FAK (chicken): S911‑p, FAK iso5 (chicken): S217‑p

S571-p - PTP-PEST (human)
Orthologous residues
PTP‑PEST (human): S571‑p, PTP‑PEST (mouse): S572‑p, PTP‑PEST (rat): S566‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
KINASE ERK1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  carcinogenesis, induced, cell motility, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces

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