Curated Information
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Curated Information Page
PubMed Id: 21876001 
Zheng Y, et al. (2011) Ras-Induced and Extracellular Signal-Regulated Kinase 1 and 2 Phosphorylation-Dependent Isomerization of Protein Tyrosine Phosphatase (PTP)-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST. Mol Cell Biol 31, 4258-69 21876001
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y397-p - FAK (human)
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y428‑p, FAK iso3 (mouse): Y397‑p, FAK iso4 (mouse): Y397‑p, FAK iso9 (mouse): , FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):

S910-p - FAK (human)
Orthologous residues
FAK (human): S910‑p, FAK iso2 (human): S737‑p, FAK iso5 (human): S923‑p, FAK (mouse): S948‑p, FAK iso3 (mouse): S910‑p, FAK iso4 (mouse): S913‑p, FAK iso9 (mouse): S218‑p, FAK (rat): S913‑p, FAK (chicken): S911‑p, FAK iso5 (chicken): S217‑p

S571-p - PTP-PEST (human)
Orthologous residues
PTP‑PEST (human): S571‑p, PTP‑PEST (mouse): S572‑p, PTP‑PEST (rat): S566‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
KINASE ERK1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  carcinogenesis, induced, cell motility, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces

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