Curated Information
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Curated Information Page
PubMed Id: 12697755 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Leach C, Shenolikar S, Brautigan DL (2003) Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. J Biol Chem 278, 26015-20 12697755
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T73-p - PPP1R2 (human)
Orthologous residues
PPP1R2 (human): T73‑p, PPP1R2 (mouse): T74‑p, PPP1R2 (rat): T73‑p, PPP1R2 (rabbit): T73‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  cervical cancer, cervical adenocarcinoma
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  primed by CKII
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mimosine decrease
nocodazole increase
GSK-3 inhibitor II nocodazole no effect upon treatment-induced increase
roscovitine nocodazole inhibit treatment-induced increase

S121-p - PPP1R2 (human)
Orthologous residues
PPP1R2 (human): S121‑p, PPP1R2 (mouse): S122‑p, PPP1R2 (rat): S121‑p, PPP1R2 (rabbit): S121‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  cervical cancer, cervical adenocarcinoma
 Cellular systems studied:  cell lines
 Species studied:  human

S122-p - PPP1R2 (human)
Orthologous residues
PPP1R2 (human): S122‑p, PPP1R2 (mouse): S123‑p, PPP1R2 (rat): S122‑p, PPP1R2 (rabbit): S122‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  cervical cancer, cervical adenocarcinoma
 Cellular systems studied:  cell lines
 Species studied:  human


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