Curated Information
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Curated Information Page
PubMed Id: 21659531 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wu SC, Zhang Y (2011) Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability. J Biol Chem 286, 28511-9 21659531
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T345-p - EZH2 (human) ▲
Orthologous residues
EZH2 (human): T345‑p, EZH2 (mouse): T345‑p, EZH2 (rat): T345‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK1 (human) modification site within consensus motif, phospho-antibody, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Effect of modification (process):  cell growth, induced

T487-p - EZH2 (human) ▲
Orthologous residues
EZH2 (human): T487‑p, EZH2 (mouse): T487‑p, EZH2 (rat): T487‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK1 (human) modification site within consensus motif, phospho-antibody, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Effect of modification (process):  cell growth, induced


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