Curated Information
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Curated Information Page
PubMed Id: 12630910 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Watanabe Y, et al. (2003) Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J 372, 465-71 12630910
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S852-p - nNOS (human)
Orthologous residues
nNOS (human): S852‑p, nNOS (mouse): S847‑p, nNOS iso5 (mouse): S881‑p, nNOS (rat): S847‑p

S847-p - nNOS (rat)
Orthologous residues
nNOS (human): S852‑p, nNOS (mouse): S847‑p, nNOS iso5 (mouse): S881‑p, nNOS (rat): S847‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) transfection of wild-type enzyme, pharmacological activator of upstream enzyme, phospho-antibody, pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
A23187 increase
KN-93 A23187 inhibit treatment-induced increase
PSD-95 (human) increase


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