Curated Information
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Curated Information Page
PubMed Id: 21677187 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Bradshaw NJ, et al. (2011) PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1. J Neurosci 31, 9043-54 21677187
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T132-p - NDEL1 (human) ▲
Orthologous residues
NDEL1 (human): T132‑p, NDEL1 (mouse): T132‑p, NDEL1 (rat): T132‑p

T131-p - NUDE1 (human) ▲
Orthologous residues
NUDE1 (human): T131‑p, NUDE1 iso2 (human): T131‑p, NUDE1 (mouse): T131‑p, NUDE1 iso3 (mouse): T131‑p, NUDE1 (rat): T131‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  adrenal cancer, pheochromocytoma
 Relevant cell lines - cell types - tissues:  COS (fibroblast), PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Comments:  PC-12 neuronal cell line (NS-1)
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKACa (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACa (human) modification site within consensus motif, phospho-motif antibody, pharmacological activator of upstream enzyme, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (human) increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein conformation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Disrupts co-immunoprecipitation
NDEL1 (human) Induces protein conformation co-immunoprecipitation
 Comments:  T131 phoshomimetic mutant inhibits neurite extension.

S306-p - NUDE1 (human) ▲
Orthologous residues
NUDE1 (human): S306‑p, NUDE1 iso2 (human): S306‑p, NUDE1 (mouse): G306‑p, NUDE1 iso3 (mouse): G306‑p, NUDE1 (rat): G306‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  adrenal cancer, pheochromocytoma
 Relevant cell lines - cell types - tissues:  COS (fibroblast), PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Comments:  PC-12 neuronal cell line (NS-1)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACa (human) modification site within consensus motif, phospho-motif antibody, pharmacological activator of upstream enzyme, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (human) increase


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