Curated Information
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Curated Information Page
PubMed Id: 12522270 
Salomon AR, et al. (2003) Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A 100, 443-8 12522270
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y333-p - Abi-1 (human)
Orthologous residues
Abi‑1 (human): Y333‑p, Abi‑1 iso2 (human): Y300‑p, Abi‑1 iso3 (human): Y306‑p, Abi‑1 iso11 (human): , Abi‑1 (mouse): Y306‑p, Abi‑1 iso4 (mouse): Y300‑p, Abi‑1 (rat): Y301‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y185-p - Abl (human)
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso2 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection], K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse

Y253-p - Abl (human)
Orthologous residues
Abl (human): Y253‑p, Abl iso2 (human): Y272‑p, Abl (mouse): Y253‑p, Abl iso2 (mouse): Y272‑p, Abl (rat): Y253‑p, Abl iso2 (rat): Y272‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y257-p - Abl (human)
Orthologous residues
Abl (human): Y257‑p, Abl iso2 (human): Y276‑p, Abl (mouse): Y257‑p, Abl iso2 (mouse): Y276‑p, Abl (rat): Y257‑p, Abl iso2 (rat): Y276‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection], K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse

T394-p - Abl (human)
Orthologous residues
Abl (human): T394‑p, Abl iso2 (human): T413‑p, Abl (mouse): T394‑p, Abl iso2 (mouse): T413‑p, Abl (rat): T394‑p, Abl iso2 (rat): T413‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection], K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse

Y827-p - Ack (human)
Orthologous residues
Ack (human): Y827‑p, Ack iso3 (human): Y905‑p, Ack (mouse): Y842‑p, Ack iso2 (mouse): Y827‑p, Ack (rat): Y827‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y859-p - Ack (human)
Orthologous residues
Ack (human): Y859‑p, Ack iso3 (human): Y937‑p, Ack (mouse): Y874‑p, Ack iso2 (mouse): Y859‑p, Ack (rat): Y859‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y860-p - Ack (human)
Orthologous residues
Ack (human): Y860‑p, Ack iso3 (human): Y938‑p, Ack (mouse): Y875‑p, Ack iso2 (mouse): Y860‑p, Ack (rat): Y860‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y177-p - Bcr (human)
Orthologous residues
Bcr (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

T310-p - Bcr (human)
Orthologous residues
Bcr (human): T310‑p, Bcr (mouse): T312‑p, Bcr (rat): T312‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

S459-p - Bcr (human)
Orthologous residues
Bcr (human): S459‑p, Bcr (mouse): S461‑p, Bcr (rat): S461‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection], K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse

S463-p - Bcr (human)
Orthologous residues
Bcr (human): S463‑p, Bcr (mouse): S465‑p, Bcr (rat): S465‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection], K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse

Y591-p - Bcr (human)
Orthologous residues
Bcr (human): Y591‑p, Bcr (mouse): Y590‑p, Bcr (rat): Y590‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y644-p - Bcr (human)
Orthologous residues
Bcr (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y166-p - Cas-L (human)
Orthologous residues
Cas‑L (human): Y166‑p, Cas‑L (mouse): Y165‑p, Cas‑L (rat): Y165‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S669-p - Cbl (human)
Orthologous residues
Cbl (human): S669‑p, Cbl (mouse): S667‑p, Cbl (rat): S668‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y674-p - Cbl (human)
Orthologous residues
Cbl (human): Y674‑p, Cbl (mouse): Y672‑p, Cbl (rat): Y673‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y149-p - CD3D (human)
Orthologous residues
CD3D (human): Y149‑p, CD3D (mouse): Y149‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y160-p - CD3D (human)
Orthologous residues
CD3D (human): Y160‑p, CD3D (mouse): Y160‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y199-p - CD3E (human)
Orthologous residues
CD3E (human): Y199‑p, CD3E (mouse): Y181‑p, CD3E (rat): Y180‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y83-p - CD3Z (human)
Orthologous residues
CD3Z (human): Y83‑p, CD3Z iso3 (human): Y83‑p, CD3Z (mouse): Y83‑p, CD3Z iso8 (mouse): Y83‑p, CD3Z (rat): Y83‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y111-p - CD3Z (human)
Orthologous residues
CD3Z (human): Y111‑p, CD3Z iso3 (human): Y110‑p, CD3Z (mouse): Y111‑p, CD3Z iso8 (mouse): Y111‑p, CD3Z (rat): Y111‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y123-p - CD3Z (human)
Orthologous residues
CD3Z (human): Y123‑p, CD3Z iso3 (human): Y122‑p, CD3Z (mouse): Y123‑p, CD3Z iso8 (mouse): Y123‑p, CD3Z (rat): Y123‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y142-p - CD3Z (human)
Orthologous residues
CD3Z (human): Y142‑p, CD3Z iso3 (human): Y141‑p, CD3Z (mouse): Y142‑p, CD3Z iso8 (mouse): Y142‑p, CD3Z (rat): Y142‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S439-p - CD5 (human)
Orthologous residues
CD5 (human): S439‑p, CD5 (mouse): S438‑p, CD5 (rat): S435‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y453-p - CD5 (human)
Orthologous residues
CD5 (human): Y453‑p, CD5 (mouse): Y452‑p, CD5 (rat): Y449‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S460-p - CD5 (human)
Orthologous residues
CD5 (human): S460‑p, CD5 (mouse): S459‑p, CD5 (rat): S456‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1068-p - CHD-1 (human)
Orthologous residues
CHD‑1 (human): Y1068‑p, CHD‑1 iso2 (human): Y1068‑p, CHD‑1 (mouse): Y1066‑p, CHD‑1 (rat): Y1066‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y421-p - Cortactin (human)
Orthologous residues
Cortactin (human): Y421‑p, Cortactin iso3 (human): Y384‑p, Cortactin (mouse): Y421‑p, Cortactin (rat): Y383‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y449-p - Dok1 (human)
Orthologous residues
Dok1 (human): Y449‑p, Dok1 (mouse): Y450‑p, Dok1 (rat): Y448‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y299-p - Dok2 (human)
Orthologous residues
Dok2 (human): Y299‑p, Dok2 (mouse): Y304‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y259-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y259‑p, Gab1 iso2 (human): Y259‑p, Gab1 (mouse): Y259‑p, Gab1 (rat): Y258‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

S266-p - Gab1 (human)
Orthologous residues
Gab1 (human): S266‑p, Gab1 iso2 (human): S266‑p, Gab1 (mouse): S266‑p, Gab1 (rat): S265‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y266-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y266‑p, Gab2 (mouse): Y263‑p, Gab2 (rat): Y263‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

T262-p - GADS (human)
Orthologous residues
GADS (human): T262‑p, GADS (mouse): T254‑p, GADS (rat): T258‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y10-p - GAGE3 (human)
Orthologous residues
GAGE3 (human): Y10‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y198-p - HS1 (human)
Orthologous residues
HS1 (human): Y198‑p, HS1 (mouse): Y198‑p, HS1 (rat): Y198‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y301-p - LPP (human)
Orthologous residues
LPP (human): Y301‑p, LPP (mouse): Y302‑p, LPP (rat): F298‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y478-p - plakophilin 4 (human)
Orthologous residues
plakophilin 4 (human): Y478‑p, plakophilin 4 iso2 (human): Y478‑p, plakophilin 4 iso4 (human): Y330‑p, plakophilin 4 (mouse): Y477‑p, plakophilin 4 iso2 (mouse): Y477‑p, plakophilin 4 iso3 (mouse): Y475‑p, plakophilin 4 (rat): Y477‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y482-p - plakophilin 4 (human)
Orthologous residues
plakophilin 4 (human): Y482‑p, plakophilin 4 iso2 (human): Y482‑p, plakophilin 4 iso4 (human): Y334‑p, plakophilin 4 (mouse): Y481‑p, plakophilin 4 iso2 (mouse): Y481‑p, plakophilin 4 iso3 (mouse): Y479‑p, plakophilin 4 (rat): Y481‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y579-p - Pyk2 (human)
Orthologous residues
Pyk2 (human): Y579‑p, Pyk2 iso2 (human): Y579‑p, Pyk2 (mouse): Y579‑p, Pyk2 (rat): Y579‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y580-p - Pyk2 (human)
Orthologous residues
Pyk2 (human): Y580‑p, Pyk2 iso2 (human): Y580‑p, Pyk2 (mouse): Y580‑p, Pyk2 (rat): Y580‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y427-p - Shc1 (human)
Orthologous residues
Shc1 (human): Y427‑p, Shc1 iso2 (human): Y317‑p, Shc1 iso3 (human): Y272‑p, Shc1 iso6 (human): Y428‑p, Shc1 iso7 (human): Y318‑p, Shc1 (mouse): Y423‑p, Shc1 iso2 (mouse): Y313‑p, Shc1 iso3 (mouse): Y268‑p, Shc1 (rat): Y423‑p, Shc1 iso2 (rat): Y313‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y671-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y671‑p, SHIP‑2 (mouse): Y672‑p, SHIP‑2 (rat): Y672‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y886-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y886‑p, SHIP‑2 (mouse): Y887‑p, SHIP‑2 (rat): Y887‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y986-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y986‑p, SHIP‑2 (mouse): Y987‑p, SHIP‑2 (rat): Y987‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

S1003-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): S1003‑p, SHIP‑2 (mouse): S1004‑p, SHIP‑2 (rat): S1004‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

S1104-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): S1104‑p, SHIP‑2 (mouse): S1105‑p, SHIP‑2 (rat): S1105‑p

Y1135-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y1135‑p, SHIP‑2 (mouse): Y1136‑p, SHIP‑2 (rat): Y1136‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1162-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y1162‑p, SHIP‑2 (mouse): Y1161‑p, SHIP‑2 (rat): Y1161‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y348-p - Syk (human)
Orthologous residues
Syk (human): Y348‑p, Syk iso2 (human): Y325‑p, Syk (mouse): Y342‑p, Syk (rat): Y342‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y352-p - Syk (human)
Orthologous residues
Syk (human): Y352‑p, Syk iso2 (human): Y329‑p, Syk (mouse): Y346‑p, Syk (rat): Y346‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human

Y292-p - ZAP70 (human)
Orthologous residues
ZAP70 (human): Y292‑p, ZAP70 (mouse): Y290‑p, ZAP70 (rat): Y290‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y315-p - ZAP70 (human)
Orthologous residues
ZAP70 (human): Y315‑p, ZAP70 (mouse): Y314‑p, ZAP70 (rat): Y310‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y319-p - ZAP70 (human)
Orthologous residues
ZAP70 (human): Y319‑p, ZAP70 (mouse): Y318‑p, ZAP70 (rat): Y314‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y492-p - ZAP70 (human)
Orthologous residues
ZAP70 (human): Y492‑p, ZAP70 (mouse): Y491‑p, ZAP70 (rat): Y487‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y493-p - ZAP70 (human)
Orthologous residues
ZAP70 (human): Y493‑p, ZAP70 (mouse): Y492‑p, ZAP70 (rat): Y488‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y185-p - Abl (mouse)
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso2 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p

Y226-p - Abl (mouse)
Orthologous residues
Abl (human): Y226‑p, Abl iso2 (human): Y245‑p, Abl (mouse): Y226‑p, Abl iso2 (mouse): Y245‑p, Abl (rat): Y226‑p, Abl iso2 (rat): Y245‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y264-p - Abl (mouse)
Orthologous residues
Abl (human): Y264‑p, Abl iso2 (human): Y283‑p, Abl (mouse): Y264‑p, Abl iso2 (mouse): Y283‑p, Abl (rat): Y264‑p, Abl iso2 (rat): Y283‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

T394-p - Abl (mouse)
Orthologous residues
Abl (human): T394‑p, Abl iso2 (human): T413‑p, Abl (mouse): T394‑p, Abl iso2 (mouse): T413‑p, Abl (rat): T394‑p, Abl iso2 (rat): T413‑p

Y469-p - Abl (mouse)
Orthologous residues
Abl (human): Y469‑p, Abl iso2 (human): Y488‑p, Abl (mouse): Y469‑p, Abl iso2 (mouse): Y488‑p, Abl (rat): Y469‑p, Abl iso2 (rat): Y488‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y91-p - Cas-L (mouse)
Orthologous residues
Cas‑L (human): Y92‑p, Cas‑L (mouse): Y91‑p, Cas‑L (rat): Y91‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y176-p - Cas-L (mouse)
Orthologous residues
Cas‑L (human): Y177‑p, Cas‑L (mouse): Y176‑p, Cas‑L (rat): Y176‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y188-p - Cas-L (mouse)
Orthologous residues
Cas‑L (human): Y189‑p, Cas‑L (mouse): Y188‑p, Cas‑L (rat): Y188‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y672-p - Cbl (mouse)
Orthologous residues
Cbl (human): Y674‑p, Cbl (mouse): Y672‑p, Cbl (rat): Y673‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

S692-p - Cbl (mouse)
Orthologous residues
Cbl (human): G694‑p, Cbl (mouse): S692‑p, Cbl (rat): S693‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y698-p - Cbl (mouse)
Orthologous residues
Cbl (human): Y700‑p, Cbl (mouse): Y698‑p, Cbl (rat): Y699‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y321-p - DYRK1A (mouse)
Orthologous residues
DYRK1A (human): Y321‑p, DYRK1A iso2 (human): Y312‑p, DYRK1A iso4 (human): Y321‑p, DYRK1A (mouse): Y321‑p, DYRK1A (rat): Y321‑p, DYRK1A (rabbit):
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y273-p - SHEP1 (mouse)
Orthologous residues
SHEP1 (human): Y278‑p, SHEP1 iso2 (human): Y121‑p, SHEP1 (mouse): Y273‑p, SHEP1 (rat): Y273‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y584-p - SHP-2 (mouse)
Orthologous residues
SHP‑2 (human): Y584‑p, SHP‑2 iso2 (human): Y580‑p, SHP‑2 (mouse): Y584‑p, SHP‑2 (rat): Y584‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  32D (myeloid) [Bcr/Abl (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse


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