Curated Information
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Curated Information Page
PubMed Id: 9624175 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cao MY, et al. (1998) Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem 273, 15765-72 9624175
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y679-p - PECAM-1 (mouse) ▲
Orthologous residues
PECAM‑1 (human): Y690‑p, PECAM‑1 (mouse): Y679‑p
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Lck (mouse) genetic transfer of wild-type enzyme
KINASE CSK (mouse) genetic transfer of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (mouse) Induces co-immunoprecipitation
SHP-2 (mouse) Induces co-immunoprecipitation
 Comments:  Y679 A.K.A. Y663

Y702-p - PECAM-1 (mouse) ▲
Orthologous residues
PECAM‑1 (human): Y713‑p, PECAM‑1 (mouse): Y702‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [PECAM-1 (mouse)]
 Cellular systems studied:  cell lines
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CSK (mouse) genetic transfer of wild-type enzyme
KINASE Lck (mouse) genetic transfer of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (mouse) Induces co-immunoprecipitation
SHP-2 (mouse) Induces co-immunoprecipitation
 Comments:  Y702 A.K.A. Y686


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