Curated Information
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Curated Information Page
PubMed Id: 12594516 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bates SH, et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-9 12594516
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Y1138-p - LEPR (mouse)
Orthologous residues
LEPR (human): Y1141‑p, LEPR iso2 (human): , LEPR (mouse): Y1138‑p, LEPR iso6 (mouse): Y1138‑p, LEPR (rat): Y1138‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  'brain, hypothalamus'
 Cellular systems studied:  tissue
 Species studied:  mouse
Downstream Regulation
 Comments:  LEPR Y985S homozygous mice are hyperphagic and obese; hypothalamic melanocortin system is suppressed; leptin failed to induce STAT3 tyrosine phosphorylation and nuclear translocation.


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