Curated Information

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Curated Information Page

PubMed Id: 12594516

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Bates SH, et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-9 12594516

Y1138-p - LEPR (mouse)

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Orthologous residues

LEPR (human): Y1141‑p, LEPR iso2 (human): ‑, LEPR (mouse): Y1138‑p, LEPR iso6 (mouse): Y1138‑p, LEPR (rat): Y1138‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: 'brain, hypothalamus'

Cellular systems studied: tissue

Species studied: mouse

Downstream Regulation

Comments: LEPR Y985S homozygous mice are hyperphagic and obese; hypothalamic melanocortin system is suppressed; leptin failed to induce STAT3 tyrosine phosphorylation and nuclear translocation.

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