Curated Information

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Curated Information Page

PubMed Id: 16621795

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Wagner LE, Betzenhauser MJ, Yule DI (2006) ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A. J Biol Chem 281, 17410-9 16621795

S1756-p - IP3R1 (rat)

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Orthologous residues

IP3R1 (human): S1764‑p, IP3R1 iso3 (human): S1716‑p, IP3R1 (mouse): S1755‑p, IP3R1 iso2 (mouse): S1740‑p, IP3R1 (rat): S1756‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
forskolin				increase
	forskolin			inhibit treatment-induced increase	IP3R1 glycine to alanine mutation that affect ATP binding (GxGxxG site mutated to GxAxxG)

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