Curated Information

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Curated Information Page

PubMed Id: 12628184

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Lee HK, et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112, 631-43 12628184

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S849-p - GluR1 (mouse)

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Orthologous residues

GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, hippocampus'

Cellular systems studied: primary cultured cells, tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NMDA				no change compared to control

Downstream Regulation

Effect of modification (function): receptor internalization, altered

Comments: Phosphorylation sites required for synaptic plasticity.

S863-p - GluR1 (mouse)

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