Curated Information
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Curated Information Page
PubMed Id: 12628184 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lee HK, et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112, 631-43 12628184
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S849-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA no change compared to control
Downstream Regulation
 Effect of modification (function):  receptor internalization, altered
 Comments:  Phosphorylation sites required for synaptic plasticity.

S863-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA decrease
Downstream Regulation
 Effect of modification (function):  receptor internalization, altered
 Comments:  Phosphorylation sites required for synaptic plasticity.


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