Curated Information
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Curated Information Page
PubMed Id: 18202149 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Faivre EJ, Daniel AR, Hillard CJ, Lange CA (2008) Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. Mol Endocrinol 22, 823-37 18202149
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1197-p - EGFR (human) ▲
Orthologous residues
EGFR (human): Y1197‑p, EGFR (mouse): Y1197‑p, EGFR (rat): Y1196‑p, EGFR (pig): Y1196‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase

S294-p - PR (human) ▲
Orthologous residues
PR (human): S294‑p, PR iso2 (human): S130‑p, PR (mouse): S294‑p, PR (rat): S293‑p, PR (chicken): G219‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase
U0126 progestin R5020 no effect upon treatment-induced increase
PP2 progestin R5020 inhibit treatment-induced increase
EGF increase
U0126 EGF inhibit treatment-induced increase

S345-p - PR (human) ▲
Orthologous residues
PR (human): S345‑p, PR iso2 (human): S181‑p, PR (mouse): ‑, PR (rat): S344‑p, PR (chicken): S259‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase
U0126 progestin R5020 no effect upon treatment-induced increase
SB203580 progestin R5020 no effect upon treatment-induced increase
PP2 progestin R5020 inhibit treatment-induced increase
AG1478 progestin R5020 inhibit treatment-induced increase
EGF no change compared to control
U0126 EGF no change compared to control
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SP1 (human) Induces co-immunoprecipitation
 Comments:  regulates expression of nonclassical PR target genes, whose promoters lack canonical PRE sequences

S400-p - PR (human) ▲
Orthologous residues
PR (human): S400‑p, PR iso2 (human): S236‑p, PR (mouse): S398‑p, PR (rat): S399‑p, PR (chicken): ‑
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase
U0126 progestin R5020 no effect upon treatment-induced increase
PP2 progestin R5020 no effect upon treatment-induced increase


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