|
Orthologous residues
|
|
ER‑alpha (human): S305‑p, ER‑alpha (mouse): S309‑p, ER‑alpha (rat): S310‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
HeLa (cervical), MCF-7 (breast cell)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
PAK1 (human)
|
antisense inhibition of upstream enzyme, mutation in upstream enzyme recognition motif, genetic transfer of constitutively active upstream enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
transcription, altered
|
