Curated Information
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Curated Information Page
PubMed Id: 12367505 
Benn SC, et al. (2002) Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron 36, 45-56 12367505
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S15-p - HSP27 (human)
Orthologous residues
HSP27 (human): S15‑p, HSP27 (mouse): S15‑p, HSP27 (rat): S15‑p, HSP27 (pig): S15‑p, HSP27 (hamster): S15‑p, HSP27 (chicken): S15‑p, HSP27 (dog): S15‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Cellular systems studied:  cell lines, primary cells, primary cultured cells
 Species studied:  human, rat
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited
 Comments:  triple mutant (S15A/S78A/S82A)

S78-p - HSP27 (human)
Orthologous residues
HSP27 (human): S78‑p, HSP27 (mouse): N82‑p, HSP27 (rat): N82‑p, HSP27 (pig): S80‑p, HSP27 (hamster): N86‑p, HSP27 (chicken): S77‑p, HSP27 (dog): S82‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Cellular systems studied:  cell lines, primary cells, primary cultured cells
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nerve damage increase
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited
 Comments:  triple mutant (S15A/S78A/S82A)

S82-p - HSP27 (human)
Orthologous residues
HSP27 (human): S82‑p, HSP27 (mouse): S86‑p, HSP27 (rat): S86‑p, HSP27 (pig): S84‑p, HSP27 (hamster): S90‑p, HSP27 (chicken): S80‑p, HSP27 (dog): S86‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Cellular systems studied:  cell lines, primary cells, primary cultured cells
 Species studied:  human, rat
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited
 Comments:  triple mutant (S15A/S78A/S82A)


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