Curated Information

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Curated Information Page

PubMed Id: 11971901

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Prajapati S, Gaynor RB (2002) Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation. J Biol Chem 277, 24331-9 11971901

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S369-p - IKK-gamma (mouse)

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Orthologous residues

IKK‑gamma (human): S376‑p, IKK‑gamma (mouse): S369‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: MEF (fibroblast) [IGF1R (mouse)]

Cellular systems studied: cell lines

Species studied: mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	IKK-beta (human)

Comments: S369 and/or S375

Downstream Regulation

Effect of modification (function): inhibition

Effect of modification (process): transcription, altered

Comments: NFKB reporter assays

S375-p - IKK-gamma (mouse)

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