Curated Information
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Curated Information Page
PubMed Id: 11971901 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Prajapati S, Gaynor RB (2002) Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation. J Biol Chem 277, 24331-9 11971901
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S369-p - IKKG (mouse)
Orthologous residues
IKKG (human): S376‑p, IKKG (mouse): S369‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IKKB (human)
 Comments:  S369 and/or S375
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  transcription, altered
 Comments:  NFKB reporter assays

S375-p - IKKG (mouse)
Orthologous residues
IKKG (human): P382‑p, IKKG (mouse): S375‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IKKB (human)
 Comments:  S369 and/or S375
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  transcription, altered
 Comments:  NFKB reporter assays


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