Curated Information
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Curated Information Page
PubMed Id: 12458207 
Barthwal MK, et al. (2003) Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 278, 3897-902 12458207
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S674-p - MLK3 (human)
Orthologous residues
MLK3 (human): S674‑p, MLK3 (mouse): S675‑p, MLK3 (rat): S675‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), HeLa (cervical), HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) genetic transfer of constitutively active upstream enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited


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