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Orthologous residues
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AP2M1 (human): T156‑p, AP2M1 iso2 (human): T154‑p, AP2M1 (mouse): T156‑p, AP2M1 (rat): T156‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
HeLa (cervical) [AP2M1 (rat)]
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Cellular systems studied:
cell lines
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Species studied:
human
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Comments:
The authors state that they identified the in vitro phosphorylation site as T156, data not shown.
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Downstream Regulation
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Effect of modification (function):
intracellular localization
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Comments:
T156A mutants are defective in the endocytosis of labelled transferrin. Although the paper demonstrates a functional correlation between T156 and endocytosis, it does not directly prove that this effect is due to phosphorylation.
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