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Orthologous residues
|
|
TOP2A (human): S1106‑p, TOP2A iso2 (human): S1132‑p, TOP2A (mouse): S1105‑p, TOP2A (rat): N1104‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, immunoprecipitation, mass spectrometry, mutation of modification site, peptide sequencing, phosphopeptide mapping
|
|
Relevant cell lines - cell types - tissues:
HL60 (myeloid)
|
|
Cellular systems studied:
cell lines
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|
Species studied:
human
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|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
BAPTA-AM
|
|
|
|
decrease
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
enzymatic activity, induced
|
|
|
