Curated Information
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PubMed Id: 16455651 
Delfino FJ, Stevenson H, Smithgall TE (2006) A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. J Biol Chem 281, 8829-35 16455651
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y713-p - Fes (human)
Orthologous residues
Fes (human): Y713‑p, Fes (mouse): Y713‑p, Fes (rat): Y713‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, yeast
 Comments:  S. cerevisiae
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
decrease M704V fes mutation
decrease R706Q fes mutation
decrease V743M fes mutation
no change compared to control S759F fes mutation (decrease compared to wt fes on fes pY713, and increase on Stat3 pY705, but marked as no change relative to other mutations or kinase inactive fes).

Y705-p - STAT3 (human)
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
decrease M704V fes mutation
decrease R706Q fes mutation
decrease V743M fes mutation
no change compared to control S759F fes mutation (decrease compared to wt fes on fes pY713, and increase on Stat3 pY705, but marked as no change relative to other mutations or kinase inactive fes).


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