Curated Information
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Curated Information Page
PubMed Id: 12427729 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Okada S, Ouchi T (2003) Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. J Biol Chem 278, 2015-20 12427729
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S988-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S988‑p, BRCA1 iso6 (human): , BRCA1 (mouse): S971‑p, BRCA1 (rat): S975‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase Ionizing radiation induces phosphorylation in S phase and G2/M phase of the cell cycle.
UV increase UV radiation induces phosphorylation during S phase of the cell cycle.
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  UV- or IR-induced phosphorylation of S988 correlates with relocalization to the perinuclear region during S phase.

S1423-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase Ionizing radiation induces phosphorylation in G2/M phase of the cell cycle.

S1497-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1497‑p, BRCA1 iso6 (human): S393‑p, BRCA1 (mouse): S1454‑p, BRCA1 (rat): S1455‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human

S1524-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1524‑p, BRCA1 iso6 (human): S420‑p, BRCA1 (mouse): S1481‑p, BRCA1 (rat): S1482‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase Ionizing radiation induces phosphorylation in S phase of the cell cycle.


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