Curated Information
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Curated Information Page
PubMed Id: 21459323 
Li Y, et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13, 376-88 21459323
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S372-p - SREBP-1 iso3 (human)
Orthologous residues
SREBP‑1 (human): S396‑p, SREBP‑1 iso3 (human): S372‑p, SREBP‑1 (mouse): S389‑p, SREBP‑1 iso4 (mouse): S323‑p, SREBP‑1 (rat): S389‑p, SREBP‑1 iso2 (rat): S365‑p
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phenformin increase
AICAR increase
S17834 increase
Downstream Regulation
 Effect of modification (function):  protein stabilization
 Effect of modification (process):  transcription, inhibited
 Comments:  inhibits proteolytic processing

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