Curated Information

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Home

Curated Information Page

PubMed Id: 11877376

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kim ST, Xu B, Kastan MB (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 16, 560-70 11877376

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S957-p - Smc1 (human)

▲

Orthologous residues

Smc1 (human): S957‑p, Smc1 (mouse): S957‑p, Smc1 (rat): S957‑p

Characterization

Methods used to characterize site in vivo: electrophoretic mobility shift, phospho-antibody

Disease tissue studied: ataxia-telangiectasic cancer

Relevant cell lines - cell types - tissues: GM01526 (fibroblast), GM0536 (fibroblast), GM0637 (fibroblast), GM09607 (fibroblast)

Cellular systems studied: cell lines, primary cultured cells

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ATM (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ATM (human)	transfection of wild-type enzyme, activation of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase
UV				increase
hydroxyurea				increase

Downstream Regulation

Effect of modification (process): cell cycle regulation

Comments: S957A and S966A mutations inhibited the S phase checkpoint in two different cell types.

S966-p - Smc1 (human)

▲