Curated Information
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Curated Information Page
PubMed Id: 21390248 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li X, et al. (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One 6, e17153 21390248
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S910-p - LRRK2 (mouse)
Orthologous residues
LRRK2 (human): S910‑p, LRRK2 (mouse): S910‑p, LRRK2 (rat): S909‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse

S912-p - LRRK2 (mouse)
Orthologous residues
LRRK2 (human): S912‑p, LRRK2 (mouse): S912‑p, LRRK2 (rat): S911‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse

S935-p - LRRK2 (mouse)
Orthologous residues
LRRK2 (human): S935‑p, LRRK2 (mouse): S935‑p, LRRK2 (rat): S934‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  kidney cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), brain, kidney, lung, spleen
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological activator of upstream enzyme, transfection of wild-type enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 gamma (mouse) Induces pull-down assay
 Comments:  reduced in LRRK2 mutants R1441G or Y1699C

S973-p - LRRK2 (mouse)
Orthologous residues
LRRK2 (human): S973‑p, LRRK2 (mouse): S973‑p, LRRK2 (rat): S972‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse


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