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Orthologous residues
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RAG2 (human): T490‑p, RAG2 (mouse): T490‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
thymocyte
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Cellular systems studied:
primary cells
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Species studied:
mouse
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Comments:
RAG2 T490A knockin mice
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Downstream Regulation
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Effect of modification (process):
carcinogenesis, altered
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Comments:
RAG2 T490A mutation induces lymphoid malignancies
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Associated Diseases
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Diseases:
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Alterations:
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Comments:
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B cell lymphoma
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mutation of site
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