Curated Information
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Curated Information Page
PubMed Id: 21349429 
Zhang L, Reynolds TL, Shan X, Desiderio S (2011) Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34, 163-74 21349429
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T490-p - RAG2 (human)
Orthologous residues
RAG2 (human): T490‑p, RAG2 (mouse): T490‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  thymocyte
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  RAG2 T490A knockin mice
Downstream Regulation
 Effect of modification (process):  carcinogenesis, altered
 Comments:  RAG2 T490A mutation induces lymphoid malignancies
Associated Diseases
Diseases: Alterations: Comments:
B cell lymphoma mutation of site

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