Curated Information
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Curated Information Page
PubMed Id: 21285358 
Amako Y, Syed GH, Siddiqui A (2011) Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein. J Biol Chem 286, 11265-74 21285358
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S132-p - COL4A3BP (human)
Orthologous residues
COL4A3BP (human): S132‑p, COL4A3BP (mouse): S132‑p, COL4A3BP (rat): S132‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Huh7 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKD1 (human) modification site within consensus motif
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S240-p - OSBP (human)
Orthologous residues
OSBP (human): S240‑p, OSBP (mouse): S238‑p, OSBP (rat): S184‑p, OSBP (rabbit): S242‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Huh7 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKD1 (human) modification site within consensus motif
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S738-p - PKD1 (human)
Orthologous residues
PKD1 (human): S738‑p, PKD1 (mouse): S744‑p, PKD1 (rat): S744‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Huh7 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection decrease
Go 6983 decrease
Go 6976 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S742-p - PKD1 (human)
Orthologous residues
PKD1 (human): S742‑p, PKD1 (mouse): S748‑p, PKD1 (rat): S748‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Huh7 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection decrease
Go 6983 decrease
Go 6976 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S910-p - PKD1 (human)
Orthologous residues
PKD1 (human): S910‑p, PKD1 (mouse): S916‑p, PKD1 (rat): S916‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Huh7 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection decrease
Go 6983 decrease
Go 6976 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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