Curated Information
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Curated Information Page
PubMed Id: 11897663 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Toyoshima-Morimoto F, Taniguchi E, Nishida E (2002) Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep 3, 341-8 11897663
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S198-p - CDC25C (human)
Orthologous residues
CDC25C (human): S198‑p, CDC25C iso3 (human): S155‑p, CDC25C (mouse): S220‑p, CDC25C (frog):
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PPP1CA (human)
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) transfection of constitutively active enzyme, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
thymidine increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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