Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 21343617 
Chen CH, et al. (2011) ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3{beta}-Mediated Phosphorylation of Rictor. Sci Signal 4, ra10 21343617
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

S9-p - GSK3B (human)
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p

Y216-p - GSK3B (human)
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit):

S641-p - GYS1 (human)
Orthologous residues
GYS1 (human): S641‑p, GYS1 (mouse): S641‑p, GYS1 (rat): S641‑p, GYS1 (rabbit): S641‑p

T982-p - PERK (human)
Orthologous residues
PERK (human): T982‑p, PERK (mouse): T980‑p, PERK (rat): T974‑p
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thapsigargin increase
tunicamycin increase

T1135-p - Rictor (human)
Orthologous residues
Rictor (human): T1135‑p, Rictor iso3 (human): T1135‑p, Rictor iso4 (human): , Rictor (mouse): T1135‑p, Rictor (rat): T1120‑p

S1235-p - Rictor (human)
Orthologous residues
Rictor (human): S1235‑p, Rictor iso3 (human): S1235‑p, Rictor iso4 (human): , Rictor (mouse): S1234‑p, Rictor (rat): S1220‑p
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human)
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thapsigargin increase
tunicamycin increase

S473-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

S9-p - GSK3B (mouse)
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p

Y216-p - GSK3B (mouse)
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit):

S641-p - GYS1 (mouse)
Orthologous residues
GYS1 (human): S641‑p, GYS1 (mouse): S641‑p, GYS1 (rat): S641‑p, GYS1 (rabbit): S641‑p

T980-p - PERK (mouse)
Orthologous residues
PERK (human): T982‑p, PERK (mouse): T980‑p, PERK (rat): T974‑p

S1234-p - Rictor (mouse)
Orthologous residues
Rictor (human): S1235‑p, Rictor iso3 (human): S1235‑p, Rictor iso4 (human): , Rictor (mouse): S1234‑p, Rictor (rat): S1220‑p


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.