Curated Information
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Curated Information Page
PubMed Id: 21219611 
Urquhart AJ, Gatei M, Richard DJ, Khanna KK (2011) ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr 2, 1 21219611
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S1349-p - CHD-4 (human)
Orthologous residues
CHD‑4 (human): S1349‑p, CHD‑4 iso2 (human): S1349‑p, CHD‑4 iso4 (human): S1342‑p, CHD‑4 (mouse): S1342‑p, CHD‑4 iso3 (mouse): S1349‑p, CHD‑4 (rat): S1342‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia, bone cancer, colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  C3ABR (lymphoblastoid), Caco-2 (intestinal), HeLa (cervical), L3 (lymphoblastoid), Seckle, U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Not reported
 Comments:  required for efficient repair of double strand DNA breaks

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