Curated Information

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Curated Information Page

PubMed Id: 21262846

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Chakraborty A, et al. (2011) Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A 108, 2205-9 21262846

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S347-p - IHPK2 (human)

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Orthologous residues

IHPK2 (human): S347‑p, IHPK2 iso4 (human): ‑, IHPK2 (mouse): S369‑p, IHPK2 (rat): S346‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting

Disease tissue studied: bone cancer

Relevant cell lines - cell types - tissues: 293 (epithelial), HeLa (cervical), U2OS (bone cell)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CK2-A1 (human)	pharmacological inhibitor of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TBB				decrease

Downstream Regulation

Effect of modification (function): protein degradation, ubiquitination

S356-p - IHPK2 (human)

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