Curated Information
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Curated Information Page
PubMed Id: 21029865 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Margolis SS, et al. (2010) EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell 143, 442-55 21029865
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y353-p - ephexin-5 (human)
Orthologous residues
ephexin‑5 (human): Y353‑p, ephexin‑5 (mouse): Y361‑p, ephexin‑5 (rat): Y346‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ephrin B1 increase
EphB2 (human) increase

Y361-p - ephexin-5 (mouse)
Orthologous residues
ephexin‑5 (human): Y353‑p, ephexin‑5 (mouse): Y361‑p, ephexin‑5 (rat): Y346‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination


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