Curated Information
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Curated Information Page
PubMed Id: 12235133 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cory GO, Garg R, Cramer R, Ridley AJ (2002) Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem 277, 45115-21 12235133
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Y291-p - WASP (human)
Orthologous residues
WASP (human): Y291‑p, WASP (mouse): Y293‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [Hck (mouse)], COS (fibroblast) [WASP (human)]
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Hck (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Hck (mouse) co-immunoprecipitation, mutation in upstream enzyme recognition motif
Downstream Regulation
 Effect of modification (function):  activity, induced
 Effect of modification (process):  cytoskeletal reorganization


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