Curated Information
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PubMed Id: 21146521 
Yoshihara K, et al. (2011) Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes. Exp Cell Res 317, 413-22 21146521
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S1601-p - Scribble iso3 (mouse)
Orthologous residues
Scribble (human): S1566‑p, Scribble iso2 (human): S1485‑p, Scribble iso3 (human): S1591‑p, Scribble (mouse): S1548‑p, Scribble iso3 (mouse): S1601‑p, Scribble (rat): S1599‑p
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  293 (epithelial), EpH4 (epithelial), L cells (fibroblast) [CDH1 (mouse), transfection], MTD-1A (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cell adhesion, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDH1 (mouse) Disrupts co-immunoprecipitation
 Comments:  interaction with E-cadherin-catenin complex

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