Curated Information

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Curated Information Page

PubMed Id: 21147781

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Herskowitz JH, et al. (2011) Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. J Biol Chem 286, 6117-27 21147781

S2206-p - SORL1 (human)

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Orthologous residues

SORL1 (human): S2206‑p, SORL1 (mouse): S2207‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site, western blotting

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ROCK2 (human)

Downstream Regulation

Effect of modification (function): protein processing

Comments: necessary for SORL1 ectodomain shedding

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