Curated Information
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Curated Information Page
PubMed Id: 11114888 
Tibbetts RS, et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 14, 2989-3002 11114888
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1143-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1143‑p, BRCA1 iso6 (human): , BRCA1 (mouse): F1106‑p, BRCA1 (rat): F1107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)

S1280-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1280‑p, BRCA1 iso6 (human): , BRCA1 (mouse): S1241‑p, BRCA1 (rat): S1242‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)

S1423-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) phospho-antibody, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
UV increase
hydroxyurea increase
aphidicolin increase


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