Curated Information
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Curated Information Page
PubMed Id: 8629002 
Rawlings DJ, et al. (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271, 822-5 8629002
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y551-p - Btk (human)
Orthologous residues
Btk (human): Y551‑p, Btk (mouse): Y551‑p, Btk (rat): Y552‑p
 Methods used to characterize site in vivo mutation of modification site, phosphopeptide mapping, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), RAMOS (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LYN (human) increase
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, intracellular localization

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